The core direction of future research should focus on directly verifying the causal relationship between local joint ferroptosis and gut microbiota dysbiosis through germ-free OA mouse models, fecal microbiota transplantation experiments, or conditional knockout models of key genes for chondrocyte-specific ferroptosis (such as GPX4 and ACSL4)
Effects of Vitamin D supplementation on resolution of fever and cough in children with pulmonary tuberculosis: a randomized double-blind controlled trial in Indonesia
Microbial/infection Many specialists have considered IC/PBS to possibly have an infectious origin (bacterial, viral, or fungal) because microorganisms like Helicobacter pylori have been found in association with the condition, which draws parallels to chronic gastritis (Atu et al., 2004
10.3969/j.issn.1673-7202.2016.11.046 32 HongY.LiB.ZhengN.WuG.MaJ.TaoX.et al (2020)
MOTS-c: The cellular energy optimizer MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a mitochondrial-derived peptide produced from DNA inside the mitochondria that helps regulate energy and improve metabolic homeostasis at the cellular level
